Glycine receptor subunit beta

Definition:

Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents.

References:

[1]. Paul S Miller, et al. Differential agonist sensitivity of glycine receptor alpha2 subunit splice variants. Br J Pharmacol. 2004 Sep;143(1):19-26. [Content Brief]

[2]. Paul S Miller, et al. Molecular basis for zinc potentiation at strychnine-sensitive glycine receptors. J Biol Chem. 2005 Nov 11;280(45):37877-84. [Content Brief]

[3]. Victoria M James, et al. Novel missense mutations in the glycine receptor β subunit gene (GLRB) in startle disease. Neurobiol Dis. 2013 Apr;52:137-49. [Content Brief]

[4]. Zhe Yang, et al. Stoichiometry and subunit arrangement of α1β glycine receptors as determined by atomic force microscopy. Biochemistry. 2012 Jul 3;51(26):5229-31. [Content Brief]

[5]. Yan Zhang, et al. Functional reconstitution of glycinergic synapses incorporating defined glycine receptor subunit combinations. Neuropharmacology. 2015 Feb;89:391-7. [Content Brief]

[6]. Mark I Rees, et al. Hyperekplexia associated with compound heterozygote mutations in the beta-subunit of the human inhibitory glycine receptor (GLRB). Hum Mol Genet. 2002 Apr 1;11(7):853-60. [Content Brief]

[7]. C A Handford, et al. The human glycine receptor beta subunit: primary structure, functional characterisation and chromosomal localisation of the human and murine genes. Brain Res Mol Brain Res. 1996 Jan;35(1-2):211-9. [Content Brief]

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