Glycine--tRNA ligase
Definition:
References:
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[1]. Xiangjing Qin, et al. Cocrystal structures of glycyl-tRNA synthetase in complex with tRNA suggest multiple conformational states in glycylation. J Biol Chem. 2014 Jul 18;289(29):20359-69. [Content Brief]
[2]. Muhammed Z Cader, et al. Crystal structure of human wildtype and S581L-mutant glycyl-tRNA synthetase, an enzyme underlying distal spinal muscular atrophy. FEBS Lett. 2007 Jun 26;581(16):2959-64. [Content Brief]
[3]. Rey-Ting Guo, et al. Crystal structures and biochemical analyses suggest a unique mechanism and role for human glycyl-tRNA synthetase in Ap4A homeostasis. J Biol Chem. 2009 Oct 16;284(42):28968-76. [Content Brief]
[4]. Stephanie N Oprescu, et al. Compound heterozygosity for loss-of-function GARS variants results in a multisystem developmental syndrome that includes severe growth retardation. Hum Mutat. 2017 Oct;38(10):1412-1420. [Content Brief]
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