Grainyhead-like protein 1 homolog

Definition:

Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3'. Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development (By similarity).; [Isoform 1]: Functions as transcription activator.; [Isoform 2]: May function as a repressor in tissues where both isoform 1 and isoform 2 are expressed.

References:

[1]. Tomasz Wilanowski, et al. Perturbed desmosomal cadherin expression in grainy head-like 1-null mice. EMBO J. 2008 Mar 19;27(6):886-97. [Content Brief]

[2]. Qianqian Ming, et al. Structural basis of gene regulation by the Grainyhead/CP2 transcription factor family. Nucleic Acids Res. 2018 Feb 28;46(4):2082-2095. [Content Brief]

[3]. Tomasz Wilanowski, et al. A highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyhead. Mech Dev. 2002 Jun;114(1-2):37-50. [Content Brief]

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