Granzyme H

Definition:

Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication.

References:

[1]. Li Wang, et al. Identification of SERPINB1 as a physiological inhibitor of human granzyme H. J Immunol. 2013 Feb 1;190(3):1319-30. [Content Brief]

[2]. Li Wang, et al. Structural insights into the substrate specificity of human granzyme H: the functional roles of a novel RKR motif. J Immunol. 2012 Jan 15;188(2):765-73. [Content Brief]

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