Growth factor receptor-bound protein 2

Definition:

Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.; [Isoform 2]: Does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.

References:

[1]. I Fath, et al. Cloning of a Grb2 isoform with apoptotic properties. Science. 1994 May 13;264(5161):971-4. [Content Brief]

[2]. E J Lowenstein, et al. The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. Cell. 1992 Aug 7;70(3):431-42. [Content Brief]

[3]. Lin Pao-Chun, et al. Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling. J Biol Chem. 2009 Dec 11;284(50):34954-63. [Content Brief]

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