GTP-binding protein 4

Definition:

Involved in the biogenesis of the 60S ribosomal subunit. Acts as TP53 repressor, preventing TP53 stabilization and cell cycle arrest.

References:

[1]. Xiaomeng Liang, et al. Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. Nat Commun. 2020 Jul 15;11(1):3542. [Content Brief]

[2]. Andrea Lunardi, et al. A genome-scale protein interaction profile of Drosophila p53 uncovers additional nodes of the human p53 network. Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6322-7. [Content Brief]

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