GTP-binding protein RAD

Definition:

May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D.

References:

[1]. Lin Chang, et al. Rad GTPase deficiency leads to cardiac hypertrophy. Circulation. 2007 Dec 18;116(25):2976-2983. [Content Brief]

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