GTPase RhebL1

Definition:

Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2.

References:

[1]. Victoria A Robb, et al. Activation of the mTOR signaling pathway in renal clear cell carcinoma. J Urol. 2007 Jan;177(1):346-52. [Content Brief]

[2]. Andrew R Tee, et al. Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1. FEBS Lett. 2005 Aug 29;579(21):4763-8. [Content Brief]

[3]. Jian Yuan, et al. Identification and characterization of RHEBL1, a novel member of Ras family, which activates transcriptional activities of NF-kappa B. Mol Biol Rep. 2005 Dec;32(4):205-14. [Content Brief]

[4]. Angel P Tabancay Jr, et al. Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K. J Biol Chem. 2003 Oct 10;278(41):39921-30. [Content Brief]

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