Guanine nucleotide-binding protein-like 3-like protein

Definition:

Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP.

References:

[1]. Qubo Zhu, et al. GNL3L stabilizes the TRF1 complex and promotes mitotic transition. J Cell Biol. 2009 Jun 1;185(5):827-39. [Content Brief]

[2]. L Meng, et al. GNL3L depletion destabilizes MDM2 and induces p53-dependent G2/M arrest. Oncogene. 2011 Apr 7;30(14):1716-26. [Content Brief]

[3]. M R K Subba Rao, et al. A novel lysine-rich domain and GTP binding motifs regulate the nucleolar retention of human guanine nucleotide binding protein, GNL3L. J Mol Biol. 2006 Dec 8;364(4):637-54. [Content Brief]

[4]. Xianming Du, et al. The homologous putative GTPases Grn1p from fission yeast and the human GNL3L are required for growth and play a role in processing of nucleolar pre-rRNA. Mol Biol Cell. 2006 Jan;17(1):460-74. [Content Brief]

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