Guanylate-binding protein 5

Definition:

As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents. Hydrolyzes GTP, but in contrast to other family members, does not produce GMP.

References:

[1]. Avinash R Shenoy, et al. GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals. Science. 2012 Apr 27;336(6080):481-5. [Content Brief]

[2]. Mark Wehner, et al. Biochemical properties of the human guanylate binding protein 5 and a tumor-specific truncated splice variant. FEBS J. 2010 Apr;277(7):1597-605. [Content Brief]

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