Guanylate kinase

Definition:

Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP). Involved in the cGMP metabolism in photoreceptors (By similarity). It may also have a role in the survival and growth progression of some tumors. In addition to its physiological role, GUK1 is essential for convert prodrugs used for the treatment of cancers and viral infections into their pharmacologically active metabolites, most notably acyclovir, ganciclovir, and 6-thioguanine and its closely related analog 6-mercaptopurine.

References:

[1]. W H Miller, et al. Phosphorylation of acyclovir (acycloguanosine) monophosphate by GMP kinase. J Biol Chem. 1980 Aug 10;255(15):7204-7. [Content Brief]

[2]. R L Miller, et al. Reassessment of the interactions of guanylate kinase and 6-thioguanosine 5'-phosphate. Biochem Pharmacol. 1977 Sep 1;26(17):1573-6. [Content Brief]

[3]. A K Field, et al. 9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine: a selective inhibitor of herpes group virus replication. Proc Natl Acad Sci U S A. 1983 Jul;80(13):4139-43. [Content Brief]

[4]. Nazimuddin Khan, et al. Solution structure and functional investigation of human guanylate kinase reveals allosteric networking and a crucial role for the enzyme in cancer. J Biol Chem. 2019 Aug 2;294(31):11920-11933. [Content Brief]

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