Guided entry of tail-anchored proteins factor 1

Definition:

Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (ER). Together with CAMLG/GET2, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required to ensure correct topology and ER insertion of CAMLG.

References:

[1]. Alison J Inglis, et al. Differential Modes of Orphan Subunit Recognition for the WRB/CAML Complex. Cell Rep. 2020 Mar 17;30(11):3691-3698.e5. [Content Brief]

[2]. Fabio Vilardi, et al. WRB and CAML are necessary and sufficient to mediate tail-anchored protein targeting to the ER membrane. PLoS One. 2014 Jan 2;9(1):e85033. [Content Brief]

[3]. Fabio Vilardi, et al. WRB is the receptor for TRC40/Asna1-mediated insertion of tail-anchored proteins into the ER membrane. J Cell Sci. 2011 Apr 15;124(Pt 8):1301-7. [Content Brief]

[4]. Hugo J F Carvalho, et al. The WRB Subunit of the Get3 Receptor is Required for the Correct Integration of its Partner CAML into the ER. Sci Rep. 2019 Aug 15;9(1):11887. [Content Brief]

[5]. Yasunori Yamamoto, et al. Molecular machinery for insertion of tail-anchored membrane proteins into the endoplasmic reticulum membrane in mammalian cells. Mol Cell. 2012 Nov 9;48(3):387-97. [Content Brief]

[6]. Sara Francesca Colombo, et al. Tail-anchored Protein Insertion in Mammals: FUNCTION AND RECIPROCAL INTERACTIONS OF THE TWO SUBUNITS OF THE TRC40 RECEPTOR. J Biol Chem. 2016 Jul 15;291(29):15292-306. [Content Brief]

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