Helicase SRCAP

Definition:

Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription.

References:

[1]. H Johnston, et al. Identification of a novel SNF2/SWI2 protein family member, SRCAP, which interacts with CREB-binding protein. J Biol Chem. 1999 Jun 4;274(23):16370-6. [Content Brief]

[2]. Joel C Eissenberg, et al. Human SRCAP and Drosophila melanogaster DOM are homologs that function in the notch signaling pathway. Mol Cell Biol. 2005 Aug;25(15):6559-69. [Content Brief]

[3]. Madeline M Wong, et al. The chromatin remodeling protein, SRCAP, is critical for deposition of the histone variant H2A.Z at promoters. J Biol Chem. 2007 Sep 7;282(36):26132-9. [Content Brief]

[4]. M A Monroy, et al. Regulation of cAMP-responsive element-binding protein-mediated transcription by the SNF2/SWI-related protein, SRCAP. J Biol Chem. 2001 Nov 2;276(44):40721-6. [Content Brief]

[5]. Donald D Ruhl, et al. Purification of a human SRCAP complex that remodels chromatin by incorporating the histone variant H2A.Z into nucleosomes. Biochemistry. 2006 May 2;45(17):5671-7. [Content Brief]

[6]. M Alexandra Monroy, et al. SNF2-related CBP activator protein (SRCAP) functions as a coactivator of steroid receptor-mediated transcription through synergistic interactions with CARM-1 and GRIP-1. Mol Endocrinol. 2003 Dec;17(12):2519-28. [Content Brief]

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