HERV-H LTR-associating protein 2

Definition:

Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.

References:

[1]. Yuwen Zhu, et al. B7-H5 costimulates human T cells via CD28H. Nat Commun. 2013;4:2043. [Content Brief]

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