Histone-lysine N-methyltransferase, H3 lysine-36 specific

Definition:

Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context.

References:

[1]. Qi Qiao, et al. The structure of NSD1 reveals an autoregulatory mechanism underlying histone H3K36 methylation. J Biol Chem. 2011 Mar 11;286(10):8361-8368. [Content Brief]

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