Homologous recombination (HR)

Definition:

Homologous recombination (HR) is a type of genetic recombination where genetic information is exchanged between two similar or identical molecules of double-stranded or single-stranded nucleic acids. Homologous recombination is a DNA metabolic process found in all forms of life that provides repair or tolerance of complex DNA damages including DNA gaps, DNA double-stranded breaks (DSBs), and DNA interstrand crosslinks (ICLs).

References:

[1]. Li X, et al. Homologous recombination in DNA repair and DNA damage tolerance. Cell Res. 2008 Jan;18(1):99-113. [Content Brief]

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