Host cell factor 1

Definition:

Transcriptional coregulator (By similarity). Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300. Coactivator for EGR2 and GABP2. Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition. Modulates expression of homeobox protein PDX1, perhaps acting in concert with transcription factor E2F1, thereby regulating pancreatic beta-cell growth and glucose-stimulated insulin secretion (By similarity). May negatively modulate transcriptional activity of FOXO3 (By similarity).; (Microbial infection) In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes.

References:

[1]. R B Scarr, et al. A novel 50-kilodalton fragment of host cell factor 1 (C1) in G(0) cells. Mol Cell Biol. 2000 May;20(10):3568-75. [Content Brief]

[2]. Randy L Luciano, et al. HCF-1 functions as a coactivator for the zinc finger protein Krox20. J Biol Chem. 2003 Dec 19;278(51):51116-24. [Content Brief]

[3]. S S Mahajan, et al. Mutations in host cell factor 1 separate its role in cell proliferation from recruitment of VP16 and LZIP. Mol Cell Biol. 2000 Feb;20(3):919-28. [Content Brief]

[4]. Bharat Khurana, et al. A protein sequestering system reveals control of cellular programs by the transcriptional coactivator HCF-1. J Biol Chem. 2004 Aug 6;279(32):33673-83. [Content Brief]

[5]. David Piluso, et al. Host cell factor-1 interacts with and antagonizes transactivation by the cell cycle regulatory factor Miz-1. J Biol Chem. 2002 Nov 29;277(48):46799-808. [Content Brief]

[6]. J L Vogel, et al. The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP. EMBO J. 2000 Feb 15;19(4):683-90. [Content Brief]

[7]. Jodi L Vogel, et al. Site-specific proteolysis of the transcriptional coactivator HCF-1 can regulate its interaction with protein cofactors. Proc Natl Acad Sci U S A. 2006 May 2;103(18):6817-22. [Content Brief]

[8]. Raoul Mazars, et al. The THAP-zinc finger protein THAP1 associates with coactivator HCF-1 and O-GlcNAc transferase: a link between DYT6 and DYT3 dystonias. J Biol Chem. 2010 Apr 30;285(18):13364-71. [Content Brief]

[9]. Yong Cai, et al. Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex. J Biol Chem. 2010 Feb 12;285(7):4268-72. [Content Brief]

[10]. Joanna Wysocka, et al. Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1. Genes Dev. 2003 Apr 1;17(7):896-911. [Content Brief]

[11]. Peipei Zhou, et al. Mixed lineage leukemia 5 (MLL5) protein regulates cell cycle progression and E2F1-responsive gene expression via association with host cell factor-1 (HCF-1). J Biol Chem. 2013 Jun 14;288(24):17532-43. [Content Brief]

[12]. Aarthi Narayanan, et al. The coactivator host cell factor-1 mediates Set1 and MLL1 H3K4 trimethylation at herpesvirus immediate early promoters for initiation of infection. Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):10835-40. [Content Brief]

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