Humanneutrophilelastase(HNE)

Definition:

Human neutrophil elastase (HNE) is a globular glycoprotein of about 30 kDa belonging to the chymotrypsin family. It consists of a single polypeptide chain of 218 amino acids and two asparaginelinked carbohydrate side chains at Asn95 and Asn144. HNE is involved in a variety of serious chronic diseases, especially cardiopulmonary pathologies.

References:

[1]. L Crocetti, et al.A patenting perspective on human neutrophil elastase (HNE) inhibitors (2014-2018) and their therapeutic applications. Expert Opin Ther Pat. 2019 Jul;29(7):555-578. [Content Brief]

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