Hyaluronidase PH-20

Definition:

Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid.

References:

[1]. M Gmachl, et al. The human sperm protein PH-20 has hyaluronidase activity. FEBS Lett. 1993 Dec 28;336(3):545-8. [Content Brief]

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