Inactive tyrosine-protein kinase PEAK1

Definition:

Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics. Acts as a scaffold for mediating EGFR signaling.

References:

[1]. Yong Zheng, et al. Temporal regulation of EGF signalling networks by the scaffold protein Shc1. Nature. 2013 Jul 11;499(7457):166-71. [Content Brief]

[2]. Yingchun Wang, et al. Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression [corrected]. Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):10920-5. [Content Brief]

[3]. Jeanne M Bristow, et al. Dynamic phosphorylation of tyrosine 665 in pseudopodium-enriched atypical kinase 1 (PEAK1) is essential for the regulation of cell migration and focal adhesion turnover. J Biol Chem. 2013 Jan 4;288(1):123-31. [Content Brief]

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