Inositol-3-phosphate synthase 1

Definition:

Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds.

References:

[1]. Shulin Ju, et al. Human 1-D-myo-inositol-3-phosphate synthase is functional in yeast. J Biol Chem. 2004 May 21;279(21):21759-65. [Content Brief]

[2]. Rania M Deranieh, et al. Phosphorylation regulates myo-inositol-3-phosphate synthase: a novel regulatory mechanism of inositol biosynthesis. J Biol Chem. 2013 Sep 13;288(37):26822-33. [Content Brief]

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