Inositol monophosphatase 1

Definition:

Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates.

References:

[1]. R Parthasarathy, et al. Brain inositol monophosphatase identified as a galactose 1-phosphatase. Brain Res. 1997 Dec 5;778(1):99-106. [Content Brief]

[2]. A J Ganzhorn, et al. The contribution of lysine-36 to catalysis by human myo-inositol monophosphatase. Biochemistry. 1996 Aug 20;35(33):10957-66. [Content Brief]

[3]. Tetsuo Ohnishi, et al. Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1. J Biol Chem. 2007 Jan 5;282(1):637-46. [Content Brief]

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