Interleukin-18 receptor accessory protein

Definition:

Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation. May play a role in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (Probable).

References:

[1]. Zenichiro Kato, et al. The structure and binding mode of interleukin-18. Nat Struct Biol. 2003 Nov;10(11):966-71. [Content Brief]

[2]. Naotaka Tsutsumi, et al. The structural basis for receptor recognition of human interleukin-18. Nat Commun. 2014 Dec 15;5:5340. [Content Brief]

[3]. K Tominaga, et al. IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells. Int Immunol. 2000 Feb;12(2):151-60. [Content Brief]

[4]. T L Born, et al. Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling. J Biol Chem. 1998 Nov 6;273(45):29445-50. [Content Brief]

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