Intermembrane lipid transfer protein VPS13A

Definition:

Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Binds phospholipids. Required for the formation or stabilization of ER-mitochondria contact sites which enable transfer of lipids between the ER and mitochondria. Negatively regulates lipid droplet size and motility. Required for efficient lysosomal protein degradation.

References:

[1]. Damian Kolakowski, et al. The GTPase Arf1 Is a Determinant of Yeast Vps13 Localization to the Golgi Apparatus. Int J Mol Sci. 2021 Nov 12;22(22):12274. [Content Brief]

[2]. Sandra Muñoz-Braceras, et al. VPS13A is closely associated with mitochondria and is required for efficient lysosomal degradation. Dis Model Mech. 2019 Feb 22;12(2):dmm036681. [Content Brief]

[3]. Wondwossen M Yeshaw, et al. Human VPS13A is associated with multiple organelles and influences mitochondrial morphology and lipid droplet motility. Elife. 2019 Feb 11;8:e43561. [Content Brief]

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