Intraflagellar transport protein 57 homolog

Definition

Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.

References:

[1]. K Sakamoto, et al. Homer1c interacts with Hippi and protects striatal neurons from apoptosis. Biochem Biophys Res Commun. 2007 Jan 5;352(1):1-5. [Content Brief]

[2]. François G Gervais, et al. Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi. Nat Cell Biol. 2002 Feb;4(2):95-105. [Content Brief]

[3]. P Majumder, et al. Interactions of HIPPI, a molecular partner of Huntingtin interacting protein HIP1, with the specific motif present at the putative promoter sequence of the caspase-1, caspase-8 and caspase-10 genes. FEBS J. 2007 Aug;274(15):3886-99. [Content Brief]

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