Intraflagellar transport protein 57 homolog

Definition:

Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.

References:

[1]. K Sakamoto, et al. Homer1c interacts with Hippi and protects striatal neurons from apoptosis. Biochem Biophys Res Commun. 2007 Jan 5;352(1):1-5. [Content Brief]

[2]. François G Gervais, et al. Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi. Nat Cell Biol. 2002 Feb;4(2):95-105. [Content Brief]

[3]. P Majumder, et al. Interactions of HIPPI, a molecular partner of Huntingtin interacting protein HIP1, with the specific motif present at the putative promoter sequence of the caspase-1, caspase-8 and caspase-10 genes. FEBS J. 2007 Aug;274(15):3886-99. [Content Brief]

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