Intraflagellar transport protein 74 homolog

Definition:

Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds beta-tubulin via its basic region. Required for ciliogenesis. Essential for flagellogenesis during spermatogenesis.

References:

[1]. Patrick Lorès, et al. A missense mutation in IFT74, encoding for an essential component for intraflagellar transport of Tubulin, causes asthenozoospermia and male infertility without clinical signs of Bardet-Biedl syndrome. Hum Genet. 2021 Jul;140(7):1031-1043. [Content Brief]

[2]. Sagar Bhogaraju, et al. Molecular basis of tubulin transport within the cilium by IFT74 and IFT81. Science. 2013 Aug 30;341(6149):1009-12. [Content Brief]

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