Jun dimerization protein 2

Definition:

Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin.

References:

[1]. M Lerdrup, et al. Depletion of the AP-1 repressor JDP2 induces cell death similar to apoptosis. Biochim Biophys Acta. 2005 Aug 15;1745(1):29-37. [Content Brief]

[2]. Chunyuan Jin, et al. Regulation of histone acetylation and nucleosome assembly by transcription factor JDP2. Nat Struct Mol Biol. 2006 Apr;13(4):331-8. [Content Brief]

[3]. Chunyuan Jin, et al. Transcriptional regulation of the c-jun gene by AP-1 repressor protein JDP2 during the differentiation of F9 cells. Nucleic Acids Res Suppl. 2002;(2):97-8. [Content Brief]

[4]. Reimi Kawaida, et al. Jun dimerization protein 2 (JDP2), a member of the AP-1 family of transcription factor, mediates osteoclast differentiation induced by RANKL. J Exp Med. 2003 Apr 21;197(8):1029-35. [Content Brief]

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