Jupiter microtubule associated homolog 2

Definition:

Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein required for NAADP-evoked intracellular calcium release. Confers NAADP-sensitivity to the two pore channels (TPCs) complex. Enables NAADP to activate Ca(2+) release from the endoplasmic reticulum through ryanodine receptors.; (Microbial infection) Involved in the endolysosomal trafficking of human coronavirus SARS-CoV-2.

References:

[1]. Gihan S Gunaratne, et al. Essential requirement for JPT2 in NAADP-evoked Ca2+ signaling. Sci Signal. 2021 Mar 23;14(675):eabd5605. [Content Brief]

[2]. Hannes G Roggenkamp, et al. HN1L/JPT2: A signaling protein that connects NAADP generation to Ca2+ microdomain formation. Sci Signal. 2021 Mar 23;14(675):eabd5647. [Content Brief]

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