Juvenile myelomonocytic leukemia

Definition:

Juvenile myelomonocytic leukemia (JMML) is a rare clonal hematopoietic disorder of early childhood with features characteristic of both myelodysplastic and myeloproliferative disorders. Recent studies have shown that abnormal proliferation is due to aberrant signal transduction resulting from mutations in components of the RAS-signaling pathway.

References:

[1]. A Borkhardt, et al. The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q. Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9168-73. [Content Brief]

[2]. Charlotte M Niemeyer, et al. JMML genomics and decisions. Hematology Am Soc Hematol Educ Program. 2018 Nov 30;2018(1):307-312. [Content Brief]

[3]. Maria Proytcheva, et al. Juvenile myelomonocytic leukemia. Semin Diagn Pathol. 2011 Nov;28(4):298-303. [Content Brief]

Biomedical Dictionary

The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

Name
Email *

	Sorry, but the email address you supplied was invalid.