Kelch-like protein 2

Definition:

Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors.

References:

[1]. Daiei Takahashi, et al. KLHL2 interacts with and ubiquitinates WNK kinases. Biochem Biophys Res Commun. 2013 Aug 2;437(3):457-62. [Content Brief]

[2]. Shuxian Jiang, et al. Process elongation of oligodendrocytes is promoted by the Kelch-related actin-binding protein Mayven. J Neurochem. 2005 Mar;92(5):1191-203. [Content Brief]

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