Krueppel-like factor 15

Definition:

Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CCN2 expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation.

References:

[1]. Yuan Lu, et al. Kruppel-like factor 15 is critical for vascular inflammation. J Clin Invest. 2013 Oct;123(10):4232-41. [Content Brief]

[2]. Joost J Leenders, et al. Regulation of cardiac gene expression by KLF15, a repressor of myocardin activity. J Biol Chem. 2010 Aug 27;285(35):27449-27456. [Content Brief]

[3]. Saptarsi M Haldar, et al. Klf15 deficiency is a molecular link between heart failure and aortic aneurysm formation. Sci Transl Med. 2010 Apr 7;2(26):26ra26. [Content Brief]

[4]. Baiqiu Wang, et al. The Kruppel-like factor KLF15 inhibits connective tissue growth factor (CTGF) expression in cardiac fibroblasts. J Mol Cell Cardiol. 2008 Aug;45(2):193-7. [Content Brief]

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