Kynurenine 3-monooxygenase
Definition:
References:
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[1]. Marta Amaral, et al. Structural basis of kynurenine 3-monooxygenase inhibition. Nature. 2013 Apr 18;496(7445):382-5. [Content Brief]
[2]. Trevor W Stone, et al. Endogenous kynurenines as targets for drug discovery and development. Nat Rev Drug Discov. 2002 Aug;1(8):609-20. [Content Brief]
[3]. Damian J Mole, et al. Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis. Nat Med. 2016 Feb;22(2):202-9. [Content Brief]
[4]. Hyun Tae Kim, et al. Structural Basis for Inhibitor-Induced Hydrogen Peroxide Production by Kynurenine 3-Monooxygenase. Cell Chem Biol. 2018 Apr 19;25(4):426-438.e4. [Content Brief]
[5]. Jingjing Gao, et al. Biochemistry and structural studies of kynurenine 3-monooxygenase reveal allosteric inhibition by Ro 61-8048. FASEB J. 2018 Apr;32(4):2036-2045. [Content Brief]
[6]. Jonathan P Hutchinson, et al. Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase. Nat Commun. 2017 Jun 12;8:15827. [Content Brief]
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