L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

Definition:

Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A, regardless of whether the CoA is presented in the free thiol form or as an acetyl thioester, to a serine residue of a broad range of acceptors including the acyl carrier domain of FASN.

References:

[1]. Gabor Bunkoczi, et al. Mechanism and substrate recognition of human holo ACP synthase. Chem Biol. 2007 Nov;14(11):1243-53. [Content Brief]

[2]. Kyle C Strickland, et al. Enzymatic properties of ALDH1L2, a mitochondrial 10-formyltetrahydrofolate dehydrogenase. Chem Biol Interact. 2011 May 30;191(1-3):129-36. [Content Brief]

[3]. Kyle C Strickland, et al. Acyl carrier protein-specific 4'-phosphopantetheinyl transferase activates 10-formyltetrahydrofolate dehydrogenase. J Biol Chem. 2010 Jan 15;285(3):1627-33. [Content Brief]

[4]. Anil K Joshi, et al. Cloning, expression, and characterization of a human 4'-phosphopantetheinyl transferase with broad substrate specificity. J Biol Chem. 2003 Aug 29;278(35):33142-9. [Content Brief]

[5]. V Praphanphoj, et al. Identification of the alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase gene, the human ortholog of the yeast LYS5 gene. Mol Genet Metab. 2001 Apr;72(4):336-42. [Content Brief]

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