Large neutral amino acids transporter small subunit 4

Definition:

Uniporter that mediates the transport of the stereospecific L-phenylalanine, L-methionine and L-branched-chain amino acids, between the extracellular space and the cytoplasm and may control the transepithelial (re)absorption of neutral amino acid in kidney and small intestine. The transport activity is mediated through facilitated diffusion and is sodium ions-, chloride ions- and pH-independent.

References:

[1]. Susanna Bodoy, et al. Identification of LAT4, a novel amino acid transporter with system L activity. J Biol Chem. 2005 Mar 25;280(12):12002-11. [Content Brief]

[2]. Lalita Oparija, et al. Anticipation of food intake induces phosphorylation switch to regulate basolateral amino acid transporter LAT4 (SLC43A2) function. J Physiol. 2019 Jan;597(2):521-542. [Content Brief]

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