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Laryngeal cancer

Definition:

Laryngeal cancer is one of the most common malignancies in Europe, with about 52,000 new cases per year, 90% of them occurring in men. Smoke and alcohol represent the major behavioral risk factors. Of all laryngeal cancers, some 95% are squamous cell carcinomas. Some molecular events have been described in laryngeal squamous cell carcinoma (LSCC). Although tumor suppressor inactivation of p53 and p16 is common in these tumors (about 50% each), oncogenic activation is less well characterized. Cyclin D1 and epidermal growth factor receptor amplification have been reported in one-third and one-quarter of LSCCs, respectively, both related to advanced stages, whereas c-myc could be amplified in 13% of cases although without associated overexpression.

References:

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[3]. Alfons Nadal, et al. Molecular biology of laryngeal squamous cell carcinoma. Virchows Arch. 2003 Jan;442(1):1-7. [Content Brief]

[4]. Christian C Abnet, et al. Carcinogenic food contaminants. Cancer Invest. 2007 Apr-May;25(3):189-96. [Content Brief]

[5]. Gerald N Wogan, et al. Environmental and chemical carcinogenesis. Semin Cancer Biol. 2004 Dec;14(6):473-86. [Content Brief]

[6]. Giovanni Almadori, et al. Molecular markers in laryngeal squamous cell carcinoma: towards an integrated clinicobiological approach. Eur J Cancer. 2005 Mar;41(5):683-93. [Content Brief]

[7]. Helmut K Seitz, et al. Molecular mechanisms of alcohol-mediated carcinogenesis. Nat Rev Cancer. 2007 Aug;7(8):599-612. [Content Brief]

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[10]. Ka-Wo Lee, et al. Different impact from betel quid, alcohol and cigarette: risk factors for pharyngeal and laryngeal cancer. Int J Cancer. 2005 Dec 10;117(5):831-6. [Content Brief]

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