Lateral signaling target protein 2 homolog

Definition:

Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated.

References:

[1]. Yaron Mosesson, et al. Monoubiquitinylation regulates endosomal localization of Lst2, a negative regulator of EGF receptor signaling. Dev Cell. 2009 May;16(5):687-98. [Content Brief]

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