Leiomodin-2

Definition:

Mediates nucleation of actin filaments and thereby promotes actin polymerization. Plays a role in the regulation of actin filament length (By similarity). Required for normal sarcomere organization in the heart, and for normal heart function.

References:

[1]. David Chereau, et al. Leiomodin is an actin filament nucleator in muscle cells. Science. 2008 Apr 11;320(5873):239-43. [Content Brief]

[2]. Malgorzata Boczkowska, et al. How Leiomodin and Tropomodulin use a common fold for different actin assembly functions. Nat Commun. 2015 Sep 15;6:8314. [Content Brief]

[3]. Michaela Yuen, et al. Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy. J Clin Invest. 2014 Nov;124(11):4693-708. [Content Brief]

[4]. Xiaorui Chen, et al. Mechanisms of leiomodin 2-mediated regulation of actin filament in muscle cells. Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12687-92. [Content Brief]

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