LETM1 domain-containing protein 1

Definition:

Involved in tumorigenesis and may function as a negative regulator of the p53/TP53. May play an essential role for mitochondrial structure and function, and thermogenesis of brown adipocytes (By similarity). May regulate phagocytosis and inflammatory responses to lipopolysaccharide in macrophages.

References:

[1]. Jesang Ko, et al. Identification and differential expression of novel human cervical cancer oncogene HCCR-2 in human cancers and its involvement in p53 stabilization. Oncogene. 2003 Jul 24;22(30):4679-89. [Content Brief]

[2]. Su-Geun Lim, et al. LETMD1 Regulates Phagocytosis and Inflammatory Responses to Lipopolysaccharide via Reactive Oxygen Species Generation and NF-κB Activation in Macrophages. J Immunol. 2020 Mar 1;204(5):1299-1309. [Content Brief]

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