Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

Definition

Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity).

References:

[1]. Sha Mi, et al. LINGO-1 negatively regulates myelination by oligodendrocytes. Nat Neurosci. 2005 Jun;8(6):745-51. [Content Brief]

[2]. Sha Mi, et al. LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex. Nat Neurosci. 2004 Mar;7(3):221-8. [Content Brief]

[3]. Jong Bae Park, et al. A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors. Neuron. 2005 Feb 3;45(3):345-51. [Content Brief]

生物医学辞典

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