Leucine-rich repeat-containing G-protein coupled receptor 5
Definition:
References:
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[1]. Wim de Lau, et al. Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. Nature. 2011 Jul 4;476(7360):293-7. [Content Brief]
[2]. Heinz Ruffner, et al. R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5. PLoS One. 2012;7(7):e40976. [Content Brief]
[3]. Andrei Glinka, et al. LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling. EMBO Rep. 2011 Sep 30;12(10):1055-61. [Content Brief]
[4]. Weng Chuan Peng, et al. Structure of stem cell growth factor R-spondin 1 in complex with the ectodomain of its receptor LGR5. Cell Rep. 2013 Jun 27;3(6):1885-92. [Content Brief]
[5]. Kendra S Carmon, et al. R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling. Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11452-7. [Content Brief]
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