Leucine-rich repeat-containing protein 14

Definition:

Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB.

References:

[1]. Chenglei Wu, et al. LRRC14 attenuates Toll-like receptor-mediated NF-κB signaling through disruption of IKK complex. Exp Cell Res. 2016 Sep 10;347(1):65-73. [Content Brief]

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