Leucine-rich repeat-containing protein 26

Definition:

Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Required for the conversion of BK alpha channels from a high-voltage to a low-voltage activated channel type in non-excitable cells. These are characterized by negative membrane voltages and constant low levels of calcium.

References:

[1]. Jiusheng Yan, et al. LRRC26 auxiliary protein allows BK channel activation at resting voltage without calcium. Nature. 2010 Jul 22;466(7305):513-6. [Content Brief]

[2]. Jiusheng Yan, et al. BK potassium channel modulation by leucine-rich repeat-containing proteins. Proc Natl Acad Sci U S A. 2012 May 15;109(20):7917-22. [Content Brief]

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