Leucine-rich repeat protein SHOC-2

Definition:

Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.

References:

[1]. Vickie Hannig, et al. A Novel SHOC2 Variant in Rasopathy. Hum Mutat. 2014 Nov;35(11):1290-4. [Content Brief]

[2]. W Li, et al. The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf. Genes Dev. 2000 Apr 15;14(8):895-900. [Content Brief]

[3]. Pablo Rodriguez-Viciana, et al. A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity. Mol Cell. 2006 Apr 21;22(2):217-30. [Content Brief]

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