Leucine zipper putative tumor suppressor 2

Definition:

Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.

References:

[1]. Gregory Thyssen, et al. LZTS2 is a novel beta-catenin-interacting protein and regulates the nuclear export of beta-catenin. Mol Cell Biol. 2006 Dec;26(23):8857-67. [Content Brief]

[2]. Haruka Sudo, et al. LAPSER1/LZTS2: a pluripotent tumor suppressor linked to the inhibition of katanin-mediated microtubule severing. Hum Mol Genet. 2008 Aug 15;17(16):2524-40. [Content Brief]

[3]. Haruka Sudo, et al. LAPSER1 is a putative cytokinetic tumor suppressor that shows the same centrosome and midbody subcellular localization pattern as p80 katanin. FASEB J. 2007 Jul;21(9):2086-100. [Content Brief]

[4]. Hyun Hwa Cho, et al. Crossregulation of beta-catenin/Tcf pathway by NF-kappaB is mediated by lzts2 in human adipose tissue-derived mesenchymal stem cells. Biochim Biophys Acta. 2008 Mar;1783(3):419-28. [Content Brief]

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