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Leukocyte cell-derived chemotaxin-2

Definition:

Has a neutrophil chemotactic activity. Also a positive regulator of chondrocyte proliferation. Does not show metalloendopeptidase activity.

References:

[1]. S Yamagoe, et al. Molecular cloning of human and bovine LECT2 having a neutrophil chemotactic activity and its specific expression in the liver. Biochim Biophys Acta. 1998 Mar 4;1396(1):105-13. [Content Brief]

[2]. Hai Zheng, et al. Crystal Structure of Human Leukocyte Cell-derived Chemotaxin 2 (LECT2) Reveals a Mechanistic Basis of Functional Evolution in a Mammalian Protein with an M23 Metalloendopeptidase Fold. J Biol Chem. 2016 Aug 12;291(33):17133-42. [Content Brief]

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