Leukotriene C4 synthase

Definition:

Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 with high specificity. Can also catalyze the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions.

References:

[1]. B K Lam, et al. Site-directed mutagenesis of human leukotriene C4 synthase. J Biol Chem. 1997 May 23;272(21):13923-8. [Content Brief]

[2]. D J Welsch, et al. Molecular cloning and expression of human leukotriene-C4 synthase. Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9745-9. [Content Brief]

[3]. Shabbir Ahmad, et al. Phosphorylation of Leukotriene C4 Synthase at Serine 36 Impairs Catalytic Activity. J Biol Chem. 2016 Aug 26;291(35):18410-8. [Content Brief]

[4]. Jesmond Dalli, et al. Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages. Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12232-12237. [Content Brief]

[5]. Shabbir Ahmad, et al. Catalytic characterization of human microsomal glutathione S-transferase 2: identification of rate-limiting steps. Biochemistry. 2013 Mar 12;52(10):1755-64. [Content Brief]

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