Ligand-dependent nuclear receptor-interacting factor 1

Definition:

Together with SMCHD1, involved in chromosome X inactivation in females by promoting the compaction of heterochromatin. Also able to repress the ligand-induced transcriptional activity of retinoic acid receptor alpha (RARA), possibly through direct recruitment of histone deacetylases. Also required for silencing of the DUX4 locus in somatic cells.

References:

[1]. Hui Joyce Li, et al. RIF-1, a novel nuclear receptor corepressor that associates with the nuclear matrix. J Cell Biochem. 2007 Nov 1;102(4):1021-35. [Content Brief]

[2]. Kohei Hamanaka, et al. Homozygous nonsense variant in LRIF1 associated with facioscapulohumeral muscular dystrophy. Neurology. 2020 Jun 9;94(23):e2441-e2447. [Content Brief]

[3]. Ryu-Suke Nozawa, et al. Human inactive X chromosome is compacted through a PRC2-independent SMCHD1-HBiX1 pathway. Nat Struct Mol Biol. 2013 May;20(5):566-73. [Content Brief]

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