LIM and senescent cell antigen-like-containing domain protein 2

Definition:

Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Plays a role in modulating cell spreading and migration.

References:

[1]. Yongjun Zhang, et al. Characterization of PINCH-2, a new focal adhesion protein that regulates the PINCH-1-ILK interaction, cell spreading, and migration. J Biol Chem. 2002 Oct 11;277(41):38328-38. [Content Brief]

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