LIM homeobox transcription factor 1-beta

Definition:

Transcription factor involved in the regulation of podocyte-expressed genes. Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels.

References:

[1]. Gentzon Hall, et al. Dysregulation of WTI (-KTS) is Associated with the Kidney-Specific Effects of the LMX1B R246Q Mutation. Sci Rep. 2017 Jan 6;7:39933. [Content Brief]

[2]. Tsuyoshi Isojima, et al. LMX1B mutation with residual transcriptional activity as a cause of isolated glomerulopathy. Nephrol Dial Transplant. 2014 Jan;29(1):81-8. [Content Brief]

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