Lipopolysaccharide-binding protein

Definition:

Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide.

References:

[1]. Hiroki Tsukamoto, et al. Lipopolysaccharide-binding protein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells. Int Immunol. 2010 Apr;22(4):271-80. [Content Brief]

[2]. Roman Jerala, et al. Structural biology of the LPS recognition. Int J Med Microbiol. 2007 Sep;297(5):353-63. [Content Brief]

[3]. S D Wright, et al. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science. 1990 Sep 21;249(4975):1431-3. [Content Brief]

[4]. Jana K Eckert, et al. The crystal structure of lipopolysaccharide binding protein reveals the location of a frequent mutation that impairs innate immunity. Immunity. 2013 Oct 17;39(4):647-60. [Content Brief]

[5]. C G Wilde, et al. Bactericidal/permeability-increasing protein and lipopolysaccharide (LPS)-binding protein. LPS binding properties and effects on LPS-mediated cell activation. J Biol Chem. 1994 Jul 1;269(26):17411-6. [Content Brief]

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